Vancomicina Biocrom may be available in the countries listed below.
Vancomycin is reported as an ingredient of Vancomicina Biocrom in the following countries:
International Drug Name Search
Generic Name: Aminocaproic Acid
Class: Hemostatics
VA Class: BL300
CAS Number: 60-32-2
A synthetic monoamino carboxylic acid that is an inhibitor of fibrinolysis.b
Treatment of excessive bleeding resulting from systemic hyperfibrinolysis and urinary fibrinolysis.b In life-threatening situations, fresh whole blood, fibrinogen infusions, and other emergency measures also may be required.b
Used in systemic hyperfibrinolysis associated with surgical complications following heart surgery (with or without cardiac bypass procedures) and portacaval shunt; in carcinoma of the lung, prostate, cervix, or stomach; in abruptio placentae; and in hematologic disorders such as amegakaryocytic thrombocytopenia accompanying aplastic anemia (reduces the need for platelet transfusions).108 b
Used in urinary fibrinolysis associated with complications of severe trauma, anoxia, and shock,a and as manifested by surgical hematuria especially following prostatectomy and nephrectomy,b or in nonsurgical hematuria accompanying polycystic or neoplastic disease of the GU tract.b
Used in conjunction with heparin therapy in patients with acute promyelocytic leukemia†; initiate therapy when plasma α2-antiplasmin (α2-plasmin inhibitor) levels have decreased to <40% of normal levels.107
Has been used effectively for the prevention of secondary ocular hemorrhage in patients with nonperforating traumatic hyphema†.100 101 102 103 104 105 106 Designated an orphan drug by FDA for topical treatment of traumatic hyphema.119
Has been used orally for the management of hereditary hemorrhagic telangiectasia†.112
Administer orally or by IV infusion.b
Administer orally if the patient is able to take oral medication.b
For solution and drug compatibility information, see Compatibility under Stability.
Administer by IV infusion.b
Avoid rapid IV administration; hypotension, bradycardia, and/or arrhythmia may result.b
For the initial infusion (loading dose), add 4–5 g of aminocaproic acid (16–20 mL of the injection) to 250 mL of diluent.b
For maintenance infusions, add 1 g of aminocaproic acid (4 mL of the injection) to 50 mL of diluent to provide a final concentration of approximately 20 mg/mL.b
Initial infusion (loading dose): Infuse 4–5 g over 1 hour in adults.b
Maintenance infusion: Infuse 1 g per hour in adults.b
100 mg/kg or 3 g/m2 during the first hour, then 33.3 mg/kg per hour or 1 g/m2 per hour (maximum 18 g/m2 in 24 hours) has been used.a Manufacturer states that safety and efficacy not established in pediatric patients.b
Initial infusion (loading dose): 100 mg/kg or 3 g/m2 over 1 hour has been used.a Manufacturer states that safety and efficacy not established in pediatric patients.b
Maintenance infusion: 33.3 mg/kg per hour or 1 g/m2 per hour (maximum 18 g/m2 in 24 hours) has been used.a Manufacturer states that safety and efficacy not established in pediatric patients.b
5 g during the first hour, then 1–1.25 g per hour for about 8 hours or until bleeding has been controlled.a b
Initial infusion (loading dose): 4–5 g over 1 hour.b
Maintenance infusion: 1 g per hour for about 8 hours or until bleeding has been controlled.b
100 mg/kg (up to 5 g) every 4 hours, up to a maximum daily dosage of 30 g, for 5 days has been used;100 101 102 103 lower daily dosages also may be effective.102
1 or 1.5 g twice daily for 1–2 months, followed by 1–2 g daily.112
Maximum 18 g/m2 in 24 hours.a
Maximum 30 g daily.100 101 102 103
Active intravascular clotting process.b
When it is not clear whether hemorrhage is secondary to primary fibrinolysis or disseminated intravascular coagulation (DIC), the distinction must be made before aminocaproic acid is administered.b Do not use without concomitant heparin therapy in patients with evidence of DIC.b
Intrarenal obstruction via glomerular capillary thrombosis or clots in the renal pelvis and ureters reported in patients with upper urinary tract bleeding.b The drug should not be used in patients with hematuria of upper urinary tract origin unless the potential benefits outweigh risks.b
Skeletal muscle weakness with necrosis of muscle fiber reported with prolonged administration.b Presentation may range from mild myalgias with weakness and fatigue to severe proximal myopathy with rhabdomyolysis, myoglobinuria, and renal failure; CK levels are elevated.b Manifestations resolve with drug discontinuance but may recur if therapy is reinstated.b
Monitor CK concentrations with long-term therapy.b Discontinue drug if an increase in CK occurs.b
If skeletal myopathy occurs, consider possibility of cardiac muscle damage.b
Aminocaproic acid injection contains as a preservative benzyl alcohol, which has been associated with toxicity (fatalities) in neonates.b (See Pediatric Precautions.)
Should be used only in acute, life-threatening situationsa involving hemorrhage resulting from hyperfibrinolysis that has been confirmed by laboratory studies.b
If aminocaproic acid is present, clots formed in vivo may not undergo spontaneous lysis as do normal clots because aminocaproic acid in the clot may inhibit spontaneous fibrinolysis.b No clear-cut evidence for in vivo drug-induced thrombosis; however, the hazard of this theoretical complication remains a possibility.b
Neurological deficits (hydrocephalus, cerebral ischemia, cerebral vasospasm) associated with use of antifibrinolytic agents in the management of subarachnoid hemorrhage.b Causal relationship to the drugs not established.b
Category C.b
Not known if aminocaproic acid is distributed into milk; caution if used in nursing women.b
Safety and efficacy not established.b 111
Large amounts of benzyl alcohol (i.e., 100–400 mg/kg daily) have been associated with toxicity (fatal “gasping syndrome”) in neonates (see Warnings); each mL of aminocaproic acid injection in multiple-dose vials contains 9 mg of benzyl alcohol.b
Nausea,b vomiting,b cramping,a abdominal pain,b diarrhea,b dizziness,b malaise,b fever,a conjunctival suffusion,a dyspnea,b nasal congestion,b headache,b edema,b pruritus,b rash.b
Drug | Interaction |
|---|---|
Anti-inhibitor coagulant complex | Increased risk of thrombosisb |
Factor IX complex | Increased risk of thrombosisb |
Rapidly and completely absorbed from the GI tract; peak plasma concentrations are attained within about 1 hour following a 5-g dose.b 111
Plasma concentrations may be higher in patients with severe renal impairment.b
Distributed through extravascular as well as intravascular compartments; penetrates human red blood cells and other body cells.b
Not known if aminocaproic acid is distributed into milk.b
Not bound.a
The major portion of aminocaproic acid is not metabolized.b 111
Eliminated principally in urine as unchanged drug (65%) and the adipic acid metabolite (11%).b 111
2 hours.b
Removed by hemodialysis; may be removed by peritoneal dialysis.b 111 121
15–30°C; tight containers.b
15–30°C; tight containers.b Do not freeze.b
15–30°C.b Do not freeze.b
For information on systemic interactions resulting from concomitant use, see Interactions.
Compatible |
|---|
Dextrose 5% in water |
Sodium chloride 0.9% |
Compatible |
|---|
Fenoldopam mesylate |
Aminocaproic acid inhibits the activation of plasminogen; also inhibits the action of fibrinolysin (plasmin).b
Importance of informing clinician of existing or contemplated concomitant therapy, including prescription and OTC drugs and dietary or herbal products.b
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.b
Importance of advising patients of other important precautionary information.b (See Cautions.)
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
Oral | Solution | 1.25 g/5 mL | Amicar Syrup (with parabens) | Xanodyne |
Aminocaproic Acid Syrup | VersaPharm | |||
Tablets | 500 mg | Amicar (with povidone; scored) | Xanodyne | |
Aminocaproic Acid Tablets | VersaPharm | |||
1 g | Amicar (with povidone; scored) | Xanodyne | ||
Parenteral | For injection concentrate, for IV infusion | 250 mg/mL (5 g) | Amicar Intravenous (with benzyl alcohol 0.9%) | Xanodyne |
Aminocaproic Acid Injection (with benzyl alcohol 0.9%) | American Regent, Hospira |
This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.
Amicar 500MG Tablets (XANODYNE PHARMACEUTICALS INC): 30/$103.39 or 90/$285.98
Aminocaproic Acid 500MG Tablets (VERSAPHARM): 100/$186.47 or 300/$539.22
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions August 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
† Use is not currently included in the labeling approved by the US Food and Drug Administration.
Only references cited for selected revisions after 1984 are available electronically.
100. Crouch ER Jr, Frenkel M. Aminocaproic acid in the treatment of traumatic hyphema. Am J Ophthalmol. 1976; 81:355-60. [IDIS 70329] [PubMed 769560]
101. McGetrick JJ, Jampol LM, Goldberg MF et al. Aminocaproic acid decreases secondary hemorrhage after traumatic hyphema. Arch Ophthalmol. 1983; 101:1031-3. [IDIS 172818] [PubMed 6870623]
102. Palmer DJ, Goldberg MF, Frenkel M et al. A comparison of two dose regimens of epsilon aminocaproic acid in the prevention and management of secondary traumatic hyphemas. Ophthalmology. 1986; 93:102-8. [PubMed 3951807]
103. Kutner B, Fourman S, Brein K et al. Aminocaproic acid reduces the risk of secondary hemorrhage in patients with traumatic hyphema. Arch Ophthalmol. 1987; 105:206-8. [IDIS 225461] [PubMed 3813951]
104. Goldfarb MS, Bulas KE, Rosenberg S et al. Aminocaproic acid treatment of recurrent postoperative hyphemas. Ann Ophthalmol. 1984; 16:690,692-3,696-7. [PubMed 6476703]
105. Goldberg MF. Antifibrinolytic agents in the management of traumatic hyphema. Arch Ophthalmol. 1983; 101:1029-30. [PubMed 6347147]
106. Love DC. Treatment of traumatic hyphema. JAMA. 1985; 253:345-6. [IDIS 194852] [PubMed 3965787]
107. Schwartz BS, Williams EC, Conlan MG et al. Epsilon-aminocaproic acid in the treatment of patients with acute promyelocytic leukemia and acquired alpha-2-plasmin inhibitor deficiency. Ann Intern Med. 1986; 105:873-7. [IDIS 223520] [PubMed 3465267]
108. Gardner FH, Helmer RE III. Aminocaproic acid: use in control of hemorrhage in patients with amegakaryocytic thrombocytopenia. JAMA. 1980; 243:35-7. [IDIS 107007] [PubMed 6965311]
109. Kang Y, Lewis JH, Navalgund A et al. Epsilon-aminocaproic acid for the treatment of fibrinolysis during liver transplantation. Anesthesiology. 1987 66:766-73. (IDIS 230629)
110. Immunex Corporation. Amicar (aminocaproic acid) syrup, tablets, and injection prescribing information. Seattle, WA; 1998 Apr 13.
111. Abbott Laboratories. Aminocaproic acid injection prescribing information. Chicago, IL; 1992 May.
112. Saba HI, Morelli GA, Logrono LA. Brief report: treatment of bleeding in hereditary hemorrhagic telangiectasia with aminocaproic acid. N Engl J Med. 1994; 330:1789-90. [IDIS 331546] [PubMed 8190155]
113. Phillips MD. Stopping bleeding in hereditary telangiectasia. N Engl J Med. 1994; 330:1822-3. [IDIS 331549] [PubMed 8190162]
114. American Academy of Pediatrics Committee on Fetus and Newborn and Committee on Drugs. Benzyl alcohol: toxic agent in neonatal units. Pediatrics. 1983; 72:356-8. [IDIS 175725] [PubMed 6889041]
115. Anon. Benzyl alcohol may be toxic to newborns. FDA Drug Bull. 1982; 12(2):10-1. [PubMed 7188569]
116. Gershanik J, Boecler B, Ensley H et al. The gasping syndrome and benzyl alcohol poisoning. N Engl J Med. 1982; 307:1384-8. [IDIS 160823] [PubMed 7133084]
117. Menon PA, Thach BT, Smith CH et al. Benzyl alcohol toxicity in a neonatal intensive care unit: incidence, symptomatology, and mortality. Am J Perinatol. 1984; 1:288-92. [PubMed 6440575]
118. Anderson CW, Ng KJ, Andresen B et al. Benzyl alcohol poisoning in a premature newborn infant. Am J Obstet Gynecol. 1984; 148:344-6. [IDIS 181207] [PubMed 6695984]
119. Food and Drug Administration. Orphan designations pursuant to section 526 of the Federal Food and Cosmetic Act as amended by the Orphan Drug Act (P.L. 97-414) to June 28, 1996. Rockville, MD; 1996 Jul.
120. Food and Drug Administration. Amicar (aminocaproic acid) syrup [September 14, 1999: Immunex]. MedWatch drug labeling changes. Rockville, MD; September 1999. From FDA website ().
121. Food and Drug Administration. Amicar (aminocaproic acid) tablets, injection, syrup [April 16, 1997: Immunex]. MedWatch drug labeling changes. Rockville, MD; April 1997. From FDA website ().
122. Mangano DT, for the Multicenter Study of Perioperative Ischemia Research Group. Aspirin and mortality from coronary bypass surgery. N Engl J Med. 2002; 347:1309-17. [IDIS 488783] [PubMed 12397188]
HID. Trissel LA. Handbook on injectable drugs. 14th ed. Bethesda, MD: American Society of Health-System Pharmacists; 2007:98.
a. AHFS drug information 2006. McEvoy GK, ed. Aminocaproic Acid. Bethesda, MD: American Society of Health-System Pharmacists; 2006:1544-46.
b. Xanodyne Pharmaceuticals. Amicar (aminocaproic acid) injection, syrup, and tablets prescribing information. Florence, KY; 2004 Sep.
c. American Academy of Pediatrics Committee on Fetus and Newborn and Committee on Drugs. Benzyl alcohol: toxic agent in neonatal units. Pediatrics. 1983; 72:356 8. [IDIS 175725] [PubMed 6889041]
d. Anon. Benzyl alcohol may be toxic to newborns. FDA Drug Bull. 1982; 12(2):10 11.
e. Centers for Disease Control. Neonatal deaths associated with use of benzyl alcohol. MMWR. 1982; 31:290 1. [IDIS 150868] [PubMed 6810084]
f. Gershanik J, Boecler B, Ensley H et al. The gasping syndrome and benzyl alcohol poisoning. N Engl J Med. 1982; 307:1384 8. [IDIS 160823] [PubMed 7133084]
g. Menon PA, Thach BT, Smith CH et al. Benzyl alcohol toxicity in a neonatal intensive care unit: incidence, symptomatology, and mortality. Am J Perinatol. 1984; 1:288 92. [PubMed 6440575]
h. Anderson CW, Ng KJ, Andresen B et al. Benzyl alcohol poisoning in a premature newborn infant. Am J Obstet Gynecol. 1984; 148:344 6. [IDIS 181207] [PubMed 6695984]
Cloflam may be available in the countries listed below.
Clobetasol 17α-propionate (a derivative of Clobetasol) is reported as an ingredient of Cloflam in the following countries:
International Drug Name Search
Generic Name: hydrocortisone rectal (cream, ointment, suppository) (hye dro KORT i zone REK tal)
Brand Names: Anucort-HC, Anumed-HC, Anusol-HC, Cortizone-10 Anal Itch Cream, Hemorrhoidal HC, Hemril-30, Hemril-HC Uniserts, Preparation H Hydrocortisone, Procto-Kit 1%, Procto-Kit 2.5%, Procto-Pak 1%, Proctocort, Proctocream-HC, Proctosert HC, Proctosol-HC, Proctozone HC, Proctozone-H, Recort Plus, Rectasol-HC, Tucks HC
Hydrocortisone is a steroid medicine that reduces inflammation in the body.
The information in this medication guide is specific to hydrocortisone rectal cream, ointment, or suppository.
Hydrocortisone rectal is used to treat itching or swelling caused by hemorrhoids or other inflammatory conditions of the rectum or anus.
Hydrocortisone rectal is also used together with other medications to treat ulcerative colitis, proctitis, and other inflammatory conditions of the lower intestines and rectal area.
Hydrocortisone rectal may also be used for purposes not listed in this medication guide.
The information in this medication guide is specific to hydrocortisone rectal cream, ointment, or suppository.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. You may need to use this medication for up to 8 weeks.
There may be other drugs that can interact with hydrocortisone rectal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Call your doctor if your symptoms do not improve or if they get worse after using this medicine for a few days.
Ask a doctor or pharmacist if it is safe for you to use this medicine if you have:
congestive heart failure;
a history of tuberculosis;
stomach ulcer or diverticulitis;
a colostomy or ileostomy;
fever or any type of infection;
kidney disease;
high blood pressure; or
myasthenia gravis.
Also tell your doctor if you have diabetes. Steroid medicines may increase the glucose (sugar) levels in your blood or urine. You may also need to adjust the dose of your diabetes medications.
Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. You may need to use this medication for up to 8 weeks.
Try to empty your bowel and bladder just before using hydrocortisone rectal.
Remove the outer wrapper from the suppository before inserting it. Avoid handling the suppository too long or it will melt in your hands. The rectal suppository can stain clothing or other fabrics it comes into contact with.
For best results from the suppository, lie down after inserting it and hold in the suppository. The suppository will melt quickly once inserted and you should feel little or no discomfort while holding it in.
For best results from the cream, use only the applicator provided with the medication. Otherwise, follow the directions provided with your rectal cream.
Apply the ointment to the rectum and surrounding skin of the rectal area as directed on the package label.
Call your doctor if your symptoms do not improve or if they get worse after using this medicine for a few days.
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
An overdose of hydrocortisone rectal is not expected to produce life-threatening symptoms. However, long-term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.
Avoid getting a vaccine during your treatment with hydrocortisone rectal. Vaccines may not work as well while you are using a steroid medicine.
feeling short of breath, even with mild exertion;
swelling of your ankles or feet;
muscle weakness;
rapid weight gain, especially in your face and midsection;
severe rectal pain or burning;
bleeding from your rectum;
severe stomach pain;
sudden and severe headache or pain behind your eyes; or
seizure (convulsions).
Less serious side effects may include:
mild rectal pain or burning;
acne;
changes in your menstrual periods;
increased sweating; or
increased facial or body hair growth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before using hydrocortisone rectal, tell your doctor if you also use insulin or take oral diabetes medication.
There may be other drugs that can interact with hydrocortisone rectal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
See also: Anucort-HC side effects (in more detail)
Anlos may be available in the countries listed below.
Loratadine is reported as an ingredient of Anlos in the following countries:
International Drug Name Search
Generic Name: technetium tc 99m pentetate (Intravenous route)
tek-NEE-shee-um Tc 99m PEN-te-tate
In the U.S.
Available Dosage Forms:
Therapeutic Class: Diagnostic Agent, Radiopharmaceutical Imaging
Technetium Tc 99m pentetate injection is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents, which may be used to find and treat certain diseases or to study the function of the body's organs.
Technetium Tc 99m pentetate injection is used to help your doctor see an image of your kidneys and assess how well they are working. It is also used to help your doctor see an image of your brain.
This medicine is to be given only by or under the direct supervision of a doctor with specialized training in nuclear medicine.
In deciding to use a diagnostic test, any risks of the test must be weighed against the good it will do. This is a decision you and your doctor will make. Also, other things may affect test results. For this test, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of technetium Tc 99m pentetate injection in the pediatric population. Safety and efficacy have not been established.
No information is available on the relationship of age to the effects of technetium Tc 99m pentetate injection in geriatric patients.
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | C | Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. |
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this diagnostic test. Make sure you tell your doctor if you have any other medical problems, especially:
This section provides information on the proper use of a number of products that contain technetium tc 99m pentetate. It may not be specific to An-DTPA. Please read with care.
A doctor or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins before you have a brain or kidney scan.
You will need to urinate right away and as often as possible for 4 to 6 hours after receiving this medicine. Drink plenty of fluids before and after receiving this medicine so you will pass more urine.
It is very important that your doctor check you closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it.
While using this medicine, you may be exposed to radiation. Talk with your doctor if you have concerns about this.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.
Ninazol may be available in the countries listed below.
Ketoconazole is reported as an ingredient of Ninazol in the following countries:
International Drug Name Search
Treating acid indigestion, heartburn, and sour stomach. It may also be used for other conditions as determined by your doctor.
Aluminum/Magnesium Concentrate is an antacid. It works by neutralizing acid in the stomach.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Aluminum/Magnesium Concentrate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Aluminum/Magnesium Concentrate. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Aluminum/Magnesium Concentrate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Aluminum/Magnesium Concentrate as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Aluminum/Magnesium Concentrate.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; diarrhea.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); loss of appetite; muscle weakness; nausea; slow reflexes; vomiting.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.
Store Aluminum/Magnesium Concentrate between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aluminum/Magnesium Concentrate out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Aluminum/Magnesium Concentrate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Treating loss of control of body movements such as muscle stiffness, slow movements, or trouble moving associated with advanced Parkinson disease.
Apomorphine is a dopamine agonist. It works by stimulating dopamine receptors, which helps improve motor function.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Apomorphine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Apomorphine. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Apomorphine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Apomorphine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Apomorphine.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Bruising, itching, pain, swelling, or redness at the injection site; dizziness; drowsiness; flushing; headache; nausea; pale skin; runny nose; vomiting; yawning.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thinking; agitation; behavior changes (eg, aggression, paranoia); chest, jaw, or left arm pain; confusion; difficulty moving; fainting; falling asleep without warning; falling down; fast or irregular heartbeat; hallucinations; increased sweating; mental or mood changes (eg, depression); new, unusual, or increased urges (eg, gambling, sexual urges); numbness of an arm or leg; painful or prolonged erection; severe dizziness, drowsiness, nausea, or vomiting; severe or persistent headache; shortness of breath; sudden, uncontrollable movements; swelling of the arms, hands, legs, or feet; unusual change in the appearance of a mole or other skin growths; vision changes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Apomorphine side effects (in more detail)
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; chest pain; confusion; difficulty moving; fainting; grogginess; lightheadedness, especially when standing; loss of consciousness; severe dizziness, nausea, or vomiting; slow heartbeat.
Store Apomorphine at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Apomorphine out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Apomorphine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Generic Name: tretinoin (Topical route)
TRET-i-noin
In the U.S.
In Canada
Available Dosage Forms:
Therapeutic Class: Dermatological Agent
Chemical Class: Retinoid
Tretinoin is used to treat acne. It works partly by keeping skin pores clear.
One of the tretinoin creams is used to treat fine wrinkles, dark spots, or rough skin on the face caused by damaging rays of the sun. It works by lightening the skin, replacing older skin with newer skin, and by slowing down the way the body removes skin cells that may have been harmed by the sun. Tretinoin works best when used within a skin care program that includes protecting the treated skin from the sun. However, it does not completely or permanently erase these skin problems or greatly improve more obvious changes in the skin, such as deep wrinkles caused by sun or the natural aging process.
Tretinoin may also be used to treat other skin diseases as determined by your doctor.
Tretinoin is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, tretinoin is used in certain patients with the following medical conditions:
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of this medicine in children with use in other age groups. Children are unlikely to have skin problems due to the sun. In older children treated for acne, tretinoin is not expected to cause different side effects or problems than it does in other age groups.
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of tretinoin in patients 50 years of age and older with use in other age groups.
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | D | Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. |
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
This section provides information on the proper use of a number of products that contain tretinoin. It may not be specific to Retin-A. Please read with care.
It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.
Do not apply this medicine to windburned or sunburned skin or on open wounds.
Do not use this medicine in or around the eyes or lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidentally gets on these areas, wash with water at once.
This medicine usually comes with patient directions. Read them carefully before using the medicine.
Before applying tretinoin, wash the skin with a mild soap or cleanser and warm water by using the tips of your fingers. Then gently pat dry. Do not scrub your face with a sponge or washcloth. Wait 20 to 30 minutes before applying this medicine to make sure the skin is completely dry. Applying tretinoin to wet skin can irritate the skin.
To use the cream or gel form of this medicine:
To use the solution form of this medicine:
After applying the medicine, wash your hands to remove any medicine that might remain on them.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
The gel product is flammable and should be kept away from fire or excessive heat.
During the first 3 weeks you are using tretinoin, your skin may become irritated. Also, your acne may seem to get worse before it gets better. It may take longer than 12 weeks before you notice full improvement of your acne, even if you use the medicine every day. Check with your health care professional at any time skin irritation becomes severe or if your acne does not improve within 8 to 12 weeks.
You should avoid washing the skin treated with tretinoin for at least 1 hour after applying it.
Avoid using any topical medicine on the same area within 1 hour before or after using tretinoin. Otherwise, tretinoin may not work properly or skin irritation might occur.
Unless your doctor tells you otherwise, it is especially important to avoid using the following skin products on the same area as tretinoin:
Using these products along with tretinoin may cause mild to severe irritation of the skin. Although skin irritation can occur, some doctors sometimes allow benzoyl peroxide to be used with tretinoin to treat acne. Usually tretinoin is applied at night so that it does not cause a problem with any other topical products that you might use during the day. Check with your doctor before using topical medicines with tretinoin.
During the first 6 months of use, avoid overexposing the treated areas to sunlight, wind, or cold weather. The skin will be more prone to sunburn, dryness, or irritation, especially during the first 2 or 3 weeks. However, you should not stop using this medicine unless the skin irritation becomes too severe. Do not use a sunlamp .
To help tretinoin work properly, regularly use sunscreen or sunblocking lotions with a sun protection factor (SPF) of at least 15. Also, wear protective clothing and hats, and apply creams, lotions, or moisturizers often.
Check with your doctor at any time your skin becomes too dry and irritated. Your health care professional can help you choose the right skin products for you to reduce skin dryness and irritation and may include the following:
In some animal studies, tretinoin has been shown to cause skin tumors to develop faster when the treated area is exposed to ultraviolet light (sunlight or artificial sunlight from a sunlamp). Other studies have not shown the same result and more studies need to be done. It is not known if tretinoin causes skin tumors to develop faster in humans.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
The side effects will go away after you stop using tretinoin. On the rare chance that your skin color changes, this effect may last for several months before your skin color returns to normal.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Retin-A Topical side effects (in more detail)
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Cedax is a brand name of ceftibuten, approved by the FDA in the following formulation(s):
No. There is currently no therapeutically equivalent version of Cedax available.
Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Cedax. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.
See also: About generic drugs.
Patents are granted by the U.S. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims.
Generic Name: aliskiren, amlodipine, and hydrochlorothiazide (AL is KYE ren, am LOE de peen, HYE droe klor oh THYE a zide)
Brand Names: Amturnide
Aliskiren is an anti-hypertensive (blood pressure lowering) medication. It works by decreasing substances in the body that narrow blood vessels and raise blood pressure.
Amlodipine is in a group of drugs called calcium channel blockers. Amlodipine relaxes (widens) blood vessels and improves blood flow.
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
The combination of aliskiren, amlodipine, and hydrochlorothiazide is used to treat high blood pressure (hypertension).
Aliskiren, amlodipine, and hydrochlorothiazide is usually given after other blood pressure medications have been tried without successful treatment of symptoms.
Aliskiren, amlodipine, and hydrochlorothiazide may also be used for purposes not listed in this medication guide.
Before you take aliskiren, amlodipine, and hydrochlorothiazide, tell your doctor if you have kidney or liver disease, glaucoma, lupus, asthma, congestive heart failure, angina (chest pain), coronary artery disease, an electrolyte imbalance (such as low potassium or magnesium), a penicillin allergy, if you are on a low-salt diet, or if you have ever had an allergic reaction to a blood pressure medication.
To make sure you can safely take aliskiren, amlodipine, and hydrochlorothiazide, tell your doctor if you have any of these other conditions:
kidney disease (or if you are on dialysis);
liver disease;
congestive heart failure;
angina (chest pain);
glaucoma;
systemic lupus erythematosus (SLE);
asthma;
coronary artery disease (hardened arteries);
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
if you are allergic to penicillin;
if you are on a low-salt diet; or
if you have ever had an allergic reaction to a blood pressure medication.
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.
Aliskiren, amlodipine, and hydrochlorothiazide may be taken with or without food, but take it the same way each time.
While using aliskiren, amlodipine, and hydrochlorothiazide, you may need blood tests at your doctor's office. Your blood pressure will need to be checked often. Visit your doctor regularly.
Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking aliskiren, amlodipine, and hydrochlorothiazide. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.
See also: Amturnide dosage (in more detail)
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include rapid heartbeats, severe dizziness, warmth or tingly feeling, and fainting.
Avoid taking with foods that are high in fat, which can make it harder for your body to absorb aliskiren, amlodipine, and hydrochlorothiazide.
swelling in your hands, ankles, or feet;
feeling like you might pass out;
vision problems, eye pain, or seeing halos around lights;
low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling); or
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.
Less serious side effects may include:
headache;
dizziness; or
stuffy nose, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all other heart or blood pressure medications you are taking.
Tell your doctor about all other medicines you use, especially:
atorvastatin (Lipitor, Caduet);
cholestyramine (Questran) or colestipol (Colestid);
furosemide (Lasix);
irbesartan (Avapro);
lithium (Eskalith, Lithobid);
quinidine (Quin-G);
simvastatin (Zocor, Simcor, Vytorin, Juvisync);
tacrolimus (Prograf);
verapamil (Calan, Covera, Isoptin, Verelan);
insulin or oral diabetes medication;
an oral, nasal, inhaled, or injectable steroid medicine;
any other diuretic (water pill);
antifungal medication such as fluconazole (Diflucan), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);
HIV or AIDS medications such as nelfinavir (Viracept), ritonavir (Norvir, Kaletra), or saquinavir (Invirase); or
non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.
This list is not complete and other drugs may interact with aliskiren, amlodipine, and hydrochlorothiazide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
See also: Amturnide side effects (in more detail)
